Cycle World via the International Motorcycle World website lists nine frugal fuel sipping motorcycles. I was at one of their shows in Washington D.C. last year. Great way to see almost every model available in one stop.
1. Honda CRF230L - 93 MPG
2. Honda Nighthawk - 90 MPG
3. Yamaha XT250 - 80 MPG
4. Aprilia SportCity 250 - 75 MPG
5. Kawasaki Ninja 250R - 60 MPG
6. Yamaha WR250X - 60 MPG
7. Suzuki GSX650F - 56 MPG
8. Harley-Davidson Sportster 883 - 55 MPG
9. Suzuki SV650 - 55 MPG
Interesting to note that a home grown Harley with an 883 cc engine gets the same mileage as many bikes with smaller displacement. And they forgot the Harley's Buell Blast with a 500 cc single cylinder that gets 64/73 mpg according to the Buell website. The bike falls into the same price bracket as others on the list.
I would love to see Harley market into the economy euro/japanese high fuel economy rider market. The market is ripe for a domestically made fuel squeezer.
Build it here and squeeze foreign oil. The concept makes me giddy.

Hayes Diversified Technologies, Hesperia, CA has a 667cc diesel motorcycle that gets 105 mpg. Production is delayed due to production requirements of the military.
I ride a BMW 800 ST which gets 67mpg. Hardly a frugal ride for this cheap soul, but it was the highest fuel mileage bike I could find with an engine that suited me that I wouldn't mind riding on an Interstate at 70 mph for 6 hours (and could get out of it's own way at that speed).
67 mpg motorcycle grocery getter camper (greenmesh.com 5/08)

The U.S. military wanted to streamline their fuel needs. Instead of multiple fuels for different vehicles they wanted to economize the distribution process with one fuel. 